Enhancing Mechanical Durability of Water-Soluble Microneedles with Cellulose Nanofibers via Thermal Imprinting (2025)

    Applications of Polymer, Composite, and Coating Materials

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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX, XXX-XXX

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    https://pubs.acs.org/doi/10.1021/acsami.5c02368

    Published April 21, 2025

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    Enhancing Mechanical Durability of Water-Soluble Microneedles with Cellulose Nanofibers via Thermal Imprinting (4)

    The study demonstrates the effectiveness of ultrahigh-pressure homogenizer (UHPH) cellulose nanofibers (CNFs) in improving the mechanical properties of poly(vinyl alcohol) (PVA) microneedle arrays (MNA). CNFs were incorporated into PVA nanocomposite films at concentrations of 0, 5, and 8 wt % using solvent casting and a nickel mold coated with a fluoropolymer was used to thermally imprint the films with MNA micropatterns at optimal mold temperatures and pressing pressure. The integration of CNFs substantially enhanced the morphological properties, surface modulus, and the accuracy of pattern replication in the nanocomposite. The augmented mechanical strength observed in the micropatterns, attributed to CNFs and subjected to UHPH treatment, can be ascribed to the physical entanglement and hydrogen bonding facilitating formation within the MNA micropattern.

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    • Carbon nanomaterials
    • DNA replication
    • Nanocomposites
    • Nanofibers
    • Transition metals

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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX, XXX-XXX

    Click to copy citationCitation copied!

    Published April 21, 2025

    Publication History

    • Received

    • Accepted

    • Revised

    • Published

      online

    © 2025 American Chemical Society

    Request reuse permissions

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